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B-Complex Plus™

What Is B-Complex Plus™?

B-Complex Plus™ is an exceptional combination of B vitamins, including vitamins B1, B2, B3, B5, B6, B12, biotin, and folic acid, all of which are provided in their optimal bioavailable and functional forms.*

Features of B-Complex Plus™ Include

• Vitamin B6 (pyridoxine HCl and pyridoxal 5’ phosphate), supporting amino acid metabolism, nervous system health, and neurotransmitter (i.e. GABA and serotonin) synthesis, which studies have reported may help promote menstrual comfort. Furthermore, pyridoxine supports healthy red blood cells by participating in hemoglobin synthesis and some studies indicate it supports wrist nerve comfort.*

• Vitamin B1 (thiamine HCl), processing carbohydrates, fat, and protein via its coenzyme form of thiamine pyrophosphate (TPP). Vitamin B1 is required to form adenosine triphosphate (ATP), the key source of energy for the body. Thiamine also promotes neural health.*

• Vitamin B2 (riboflavin and riboflavin 5’ phosphate), metabolizing nutrients and participating in electron transport to form ATP. Riboflavin is an integral part of fatty acid catabolism or β-oxidation and helps convert folic acid and vitamins B6 to their active states.*

• Vitamin B3 (niacinamide and inositol hexaniacinate), supporting cardiovascular health by mediating healthy lipid and carbohydrate metabolism.*

• Vitamin B5 (calcium pantothenate), supporting cardiovascular health. Pantothenic acid is vital in the healthy production, transportation, and breakdown of lipids. Furthermore, this B vitamin promotes the production of the neurotransmitter acetylcholine.*

• Vitamin B12 (methylcobalamin), supporting healthy nerve cell activity and DNA replication. Vitamin B12 is a vital component of the methionine synthase pathway, which along with folic acid and vitamin B6 supports healthy homocysteine metabolism and S-adenosylmethionine (SAMe) production.*

• Folic acid, promoting the production of healthy DNA and chromosomes. In particular, this B vitamin is critical for the proper neural and cellular development of the fetal central nervous system, helping to prevent neural tube defects. In conjunction with vitamins B12 and B6, folic acid helps to support healthy homocysteine metabolism. Additionally, this B vitamin is important for the growth and reproduction of red and white blood cells.*†

• Biotin, acting as a coenzyme for the metabolism of fat, carbohydrates and protein.*

Uses For B-Complex Plus™

These B vitamins play important roles in nearly all of the physiological systems in the body.

Some of the key supportive roles include:

  • the maintenance of muscle tone in the GI tract,
  • the functioning of the nervous system, and
  • the integrity of skin, hair, and the liver.

Furthermore, these compounds are essential for healthy fetal neural development, hemoglobin formation, nerve impulse transmissions, mood, hormone synthesis, and energy metabolism.*†

Source for B-Complex Plus™

Pure Encapsulations B-Complex Plus™ formula contains:

Vitamin B1 (thiamine HCl):
synthetic Vitamin B2 (riboflavin):
corn dextrose fermentation Niacinamide and Inositol hexaniacinate:
synthetic Vitamin B5 (calcium pantothenate):
synthetic Vitamin B6 (pyridoxal HCl):
synthetic Vitamin B12 (methylcobalamin):
corn dextrose fermentation Folic acid:
synthetic Biotin:

synthetic Vitamin C (ascorbyl palmitate) is derived from corn dextrose fermentation and palm oil.

 Potential Side Effects Or Precautions - B-Complex Plus™

At this time, there are no known side effects or precautions. If pregnant or lactating, consult your physician before taking this product.

Potential Drug Interactions - B-Complex Plus™

Folic acid may adversely interact with chemotheraputic drugs.

Ingredients and Dosage

each B-Complex Plus™ vegetable capsule contains

thiamine HCl (B1) - 100 mg.
riboflavin (B2) - 5 mg.
riboflavin 5' phosphate (activated B2)- 10 mg.
niacinamide - 100 mg.
inositol hexaniacinate (no-flush niacin) - 10 mg.
pyridoxine HCl (B6) - 10 mg.
pyridoxal 5' phosphate (activated B6) - 10 mg.
pantothenic acid (calcium pantothenate) (B5) - 100 mg.
methylcobalamin (B12) - 400 mcg.
folic acid - 400 mcg.**
biotin - 400 mcg.
vitamin C (as ascorbyl palmitate) - 16 mg.

**2 capsules provide the recommended dose for pregnant or lactating women.

Recommended Dosage:

1–2 capsules per day, in divided doses, with meals.


1. Fujii A, Matsumoto H, Yamamoto H. Effect of vitamin B complex on neurotransmission and neurite outgrowth. Gen Pharmacol1996 Sep;27(6):995-1000.

2. Kienecker EW, Becker KW, Dick P. Modification of degenerative and regenerative processes in peripheral nerves by treatment with B vitamins. Klin Wochenschr1990 Jan 19;68(2):146-8.

3. Bell IR, Edman JS, Morrow FD, Marby DW, Mirages S, Perrone G, Kayne HL, Cole JO. B complex vitamin patterns in geriatric and young adult inpatients with major depression. J Am Geriatr Soc1991 Mar;39(3):252-7.

4. Hasegawa K, Mikuni N, Sakai Y. Effects of a vitamin B complex on functional recovery after nerve injury. Nippon Yakurigaku Zasshi 1978 Sep;74(6):721-34.

5. Selhub J; Jacques PF; Wilson PW; Rush D; Rosenberg IH; Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA1993 Dec 8;270(22):2693-8.

6. Healthnotes Clinical Essentials. Copyright 2004. Healthnotes, Inc.

*This is a statement of nutritional support. This statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

†Women who consume healthful diets with adequate folate may reduce their risk of having a child with birth defects of the brain or spinal cord. Folate intake should not exceed 250% of the DV (1,000 mcg).

This information is for educational purposes only. Consult your physician for any health problems.

Source: Product Information Sheet from Pure Encapsulations

Manufacturers continually change product specifications. While we try our best to keep product descriptions up to date, they do not necessarily reflect the latest information available from the manufacturer. We are not responsible for incorrect or outdated product descriptions and/or images.

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