Acetyl-l-Carnitine
What Is Acetyl-l-Carnitine?
Acetyl-l-carnitine is the acetylated form of l-carnitine. The
two compounds share similar energy and metabolism
promoting properties. Found naturally in the body,
acetyl-l-carnitine supports the availability of acetyl-CoA,
an important energy generating metabolite. In addition, it
supports proper mitochondrial function and cell
membrane stability. The acetyl group from acetyl-l-carnitine
is also responsible for the production of acetylcholine,
an important neurotransmitter for optimal mental
functioning.*
Uses For Acetyl-l-Carnitine
Support For Cognitive Function, Memory, And Emotional
Well-Being:
The efficacy of long-term acetyl-l-carnitine
supplementation was determined in a double blind,
placebo-controlled, randomized trial involving 130 elderly
individuals for a one-year period. In this trial,
acetyl-l-carnitine demonstrated the ability to slow
negative cognitive changes, and supported memory and
attention.
In another randomized double blind study, three-month acetyl-l-carnitine
supplementation provided
statistically significant support for mental function,
including memory and attention, compared to placebo.
A multicenter trial of 481 volunteers showed significant
memory, behavioral and emotional support with
acetyl-l-carnitine supplementation. In an evaluation of 28
elderly individuals using acetyl-l-carnitine or placebo, the
supplemented group experienced enhanced emotional
well-being.*
Source of Acetyl-l-Carnitine
Acetyl-l-carnitine is derived from
acetyl-l-carnitine HCl, a synthetically derived amino acid.
Potential Side Effects Or Precautions When Using Acetyl-l-Carnitine
If pregnant or lactating, consult your physician before taking
this product.
Gastrointestinal upset and skin rash have been
reported in sensitive individuals.
Potential Drug Interactions of Acetyl-l-Carnitine
At this time, there are no known adverse reactions when
taken in conjunction with medications.
Ingredients
Acetyl-l-Carnitine 250 mg.
Each vegetable capsule contains
acetyl-l-carnitine HCl - 250 mg.
vitamin C (as ascorbyl palmitate) - 4 mg.
(hypo-allergenic plant fiber added to complete capsule volume requirement)
Recommended Dosage for Acetyl-l-Carnitine 250 mg
2–4 capsules per day, in divided doses, between meals.
Acetyl-l-Carnitine 500 mg.
each vegetable capsule contains
acetyl-l-carnitine HCl - 500 mg.
vitamin C (as ascorbyl palmitate) - 8 mg.
(hypo-allergenic plant fiber added to complete capsule volume requirement)
Recommended Dosage for Acetyl-l-Carnitine 500 mg
1–2 capsules per day, in divided doses, between meals.
References
1. Montgomery SA, Thal LJ, Amrein R. Meta-analysis of double blind randomized
controlled clinical trials of acetyl-l-carnitine versus placebo in the
treatment of mild cognitive impairment and mild Alzheimer’s disease. Int
Clin Psychopharmacol2003 Mar;18(2):61-71.
2. Thal LJ, Carta A, Clarke WR, et al. A 1-year multicenter
placebo-controlled
study of acetyl-L-carnitine in patients with Alzheimer’s disease.
Neurology1996;47:705–11.
3. Pettegrew JW, Klunk WE, Panchalingam K, et al. Clinical and neurochemical
effects of acetyl-L-carnitine in Alzheimer’s disease. Neurobiol Aging
1995;16:1-4.
4. Cucinotta D, Passeri M, Ventura S, et al. Multicenter clinical
placebocontrolled
study with acetyl-L-carnitine (LAC) in the treatment of mildly
demented elderly patients. Drug Development Res1988;14:213-6.
5. Garzya G et al. Evaluation of the effects of L-acetylcarnitine on senile
patients suffering from depression. Drugs Exp Clin Res.1990;16(2):101-6.
6. Salvioli G, Neri M. L-acetylcarnitine treatment of mental decline in the
elderly. Drugs Exp Clin Res.1994;20(4):169-76.
7. Healthnotes Clinical Essentials. Copyright 2004. Healthnotes, Inc.
*This is a statement of nutritional support. This statement has not been
evaluated by the Food & Drug Administration. This product is not intended to
diagnose, treat, cure or prevent any disease.
This information is for educational purposes only. Consult your physician for
any health problems.
Source: Product Information Sheet from Pure Encapsulations
Manufacturers continually change product
specifications. While we try our best to keep product descriptions up to date,
they do not necessarily reflect the latest information available from the
manufacturer. We are not responsible for incorrect or outdated product
descriptions and/or images.
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